The problems will be categorized by topic chapters for ease of reference and use in courses. They will provide a valuable resource for instructors, providing a means of testing and developing the many principles covered in texts and advanced courses. Often students find it difficult to find practical problems to test the principles they have learned in class.
This text will provide a series of questions to test understanding and worked examples as a pedagogical aid. Written by major contributors to the field, this book provides students with an introduction and overview of bioinorginic chemistry and gives them the background required to read and follow the current research literature. Each chapter is designed to define and teach underlying principles of bioinorganic chemistry while at the same time describing the state of current knowledge about the particular topic of the chapter.
This text-reference is suitable for use in advanced undergraduate and graduate courses.
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Principles of Bioinorganic Chemistry by Stephen J. As one of the most dynamic fields in contemporary science, bioinorganic chemistry lies at a natural juncture between chemistry, biology, and medicine. This rapidly expanding field probes fascinating questions about the uses of metal ions in nature. Respiration, metabolism, photosynthesis, gene regulation, and nerve impulse transmission are a few of the many natural processes that require metal ions, and new systems are continually being discovered.
The use of unnatural metals - which have been introduced into human biology as diagnostic probes and drugs - is another active area of tremendous medical significance. This introductory text, written by two pioneering researchers, is destined to become a landmark in the field of bioinorganic chemistry through its organized unification of key topics.
Description - Biosciences - University of Exeter
Accessible to undergraduates, the book provides necessary background information on coordination chemistry, biochemistry, and physical methods before delving into topics that are central to the field: What metals are chosen and how are they taken up by cells? How are the concentrations of metals controlled and utilized in cells? How do metals bind to and fold biomolecules? What principles govern electron transfer and substrate binding and activation reactions?
How do proteins fine-tune the properties of metals for specific functions? For each topic discussed, fundamentals are identified and then clarified through selected examples. An extraordinarily readable writing style combines with chapter-opening principles, study problems, and beautifully rendered two-color illustrations to make this book an ideal choice for instructors, students, and researchers in the chemical, biological, and medical communities. This book provides a clear and concise introduction to the rapidly growing field of bioinorganic chemistry.
The first part of the book deals with the function and occurrence of inorganic elements in living organisms, while later chapters address the applications of these biominerals, inorganic electrolytes and inorganic compounds in fields such as chemotherapy and radiodiagnostics. This text provides detailed coverage of physical methods used in bioinorganic chemistry.
By integrating theory with experimentation, and providing a more biological orientation, the book aims to serve as a major textbook for students of bioinorganic chemistry. Scott Editor ; Charles M.
Module aims - intentions of the module
Modern spectroscopic and instrumental techniques are essential to the practice of inorganic and bioinorganic chemistry. This first volume in the new Wiley Encyclopedia of Inorganic Chemistry Methods and Applications Series provides a consistent and comprehensive description of the practical applicability of a large number of techniques to modern problems in inorganic andbioinorganic chemistry. The outcome is a text that provides invaluable guidance and advice for inorganic and bioinorganic chemists to select appropriate techniques, whilst acting as asource to the understanding of these methods.
This set combines all volumes published as EIC Books from to , representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic. Solomon Editor ; Robert A. Scott Editor ; R. Over the past several decades there have been major advances in our ability to computationally evaluate the electronic structure of inorganic molecules, particularly transition metal systems.
This advancement is due to the Moore's Law increase in computing power as well as the impact of density functional theory DFT andits implementation in commercial and freeware programs for quantum chemical calculations. Improved pure and hybrid density functionals are allowing DFT calculations with accuracy comparable to high-level Hartree-Fock treatments, and the results of these calculations can now be evaluated by experiment.
When calculations are correlated to, and supported by,experimental data they can provide fundamental insight into electronic structure and its contributions to physical properties and chemical reactivity. This interplay continues to expand and contributes to both improved value of experimental results and improved accuracy of computational predictions. The purpose of this EIC Book is to provide state-of-the-art presentations of quantum mechanical and related methods and their applications, written by many of the leaders in the field. Part 1of this volume focuses on methods, their background and implementation, and their use in describing bonding properties,energies, transition states and spectroscopic features.
Part 2focuses on applications in bioinorganic chemistry and Part 3discusses inorganic chemistry, where electronic structure calculations have already had a major impact. This addition to the EIC Book series is of significant value to both experimentalists and theoreticians, and we anticipate that it will stimulate both further development of the methodology and its applications in the many interdisciplinary fields that comprise modern inorganic and bioinorganic chemistry.
Inorganic Chemistry 5th Ed by Gary L. With its updates to quickly changing content areas, a strengthened visual presentation and the addition of new co-author Paul Fischer, the new edition of this highly readable text is more educational and valuable than ever. Strong coverage of atomic theory and an emphasis on physical chemistry provide a firm understanding of the theoretical basis of inorganic chemistry, while a reorganized presentation of molecular orbital and group theory highlights key principles more clearly.
Inorganic Chemistry 4th Ed by Gary L. This highly readable text provides the essentials of Inorganic Chemistry at a level that is neither too high nor too low. Praised for its coverage of theoretical inorganic chemistry, it discusses molecular symmetry earlier than other texts and builds on this foundation in later chapters.
Plenty of supporting book references encourage you to further explore topics of interest. Inorganic Chemistry 3rd Ed by Gary L. This highly readable book provides the essentials of Inorganic Chemistry with molecular symmetry as its foundation. Chapter topics include atomic structure, molecular orbitals, organometallic chemistry, simple bonding theory, symmetry and group theory, and more. For chemists and other professionals who want to update or improve their background in the field.
The bestselling textbook inorganic chemistry text on the market covers both theoretical and descriptive aspects of the subject, and emphasizes experimental methods, industrial applications, and modern topics. Since its first edition in , this extraordinary textbook has helped shape the way biochemistry is taught, offering exceptionally clear writing, innovative graphics, coverage of the latest research techniques and advances, and a signature emphasis on physiological and medical relevance.
Those defining features are at the heart of the new Seventh Edition of Biochemistry, which again communicates fundamental concepts and the latest breakthroughs in a way that makes the information engaging and understandable for students approaching the subject for the first time. Biochemistry 6th Ed by Jeremy M. Berg; Lubert Stryer; John L. This books has exceptional clarity and concision, a more biological focus, cutting-edge content, and an elegant, uncluttered design.
Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry. A topical theme within this specialization is supramolecular coordination chemistry. Due to their often similar reactivity, the elements in group 3 Sc , Y , and La and group 12 Zn , Cd , and Hg are also generally included, and the lanthanides and actinides are sometimes included as well.
Main group compounds have been known since the beginnings of chemistry, e. Experiments on oxygen, O 2 , by Lavoisier and Priestley not only identified an important diatomic gas, but opened the way for describing compounds and reactions according to stoichiometric ratios. The discovery of a practical synthesis of ammonia using iron catalysts by Carl Bosch and Fritz Haber in the early s deeply impacted mankind, demonstrating the significance of inorganic chemical synthesis.
Main group compounds also occur in nature, e. Compounds containing metals from group 4 to 11 are considered transition metal compounds. Compounds with a metal from group 3 or 12 are sometimes also incorporated into this group, but also often classified as main group compounds. Transition metal compounds show a rich coordination chemistry, varying from tetrahedral for titanium e.
A range of transition metals can be found in biologically important compounds, such as iron in hemoglobin. Usually, organometallic compounds are considered to contain the M-C-H group. Operationally, the definition of an organometallic compound is more relaxed to include also highly lipophilic complexes such as metal carbonyls and even metal alkoxides.
Organometallic compounds are mainly considered a special category because organic ligands are often sensitive to hydrolysis or oxidation, necessitating that organometallic chemistry employs more specialized preparative methods than was traditional in Werner-type complexes. Synthetic methodology, especially the ability to manipulate complexes in solvents of low coordinating power, enabled the exploration of very weakly coordinating ligands such as hydrocarbons, H 2 , and N 2.
Because the ligands are petrochemicals in some sense, the area of organometallic chemistry has greatly benefited from its relevance to industry. Clusters can be found in all classes of chemical compounds. According to the commonly accepted definition, a cluster consists minimally of a triangular set of atoms that are directly bonded to each other.
But metal-metal bonded dimetallic complexes are highly relevant to the area. Clusters occur in "pure" inorganic systems, organometallic chemistry, main group chemistry, and bioinorganic chemistry. The distinction between very large clusters and bulk solids is increasingly blurred. This interface is the chemical basis of nanoscience or nanotechnology and specifically arise from the study of quantum size effects in cadmium selenide clusters.
Thus, large clusters can be described as an array of bound atoms intermediate in character between a molecule and a solid. By definition, these compounds occur in nature, but the subfield includes anthropogenic species, such as pollutants e.
Traditionally bioinorganic chemistry focuses on electron- and energy-transfer in proteins relevant to respiration. Medicinal inorganic chemistry includes the study of both non-essential and essential elements with applications to diagnosis and therapies. This important area focuses on structure ,  bonding, and the physical properties of materials.
In practice, solid state inorganic chemistry uses techniques such as crystallography to gain an understanding of the properties that result from collective interactions between the subunits of the solid. Included in solid state chemistry are metals and their alloys or intermetallic derivatives. Related fields are condensed matter physics , mineralogy , and materials science. An alternative perspective on the area of inorganic chemistry begins with the Bohr model of the atom and, using the tools and models of theoretical chemistry and computational chemistry , expands into bonding in simple and then more complex molecules.
Precise quantum mechanical descriptions for multielectron species, the province of inorganic chemistry, is difficult. This challenge has spawned many semi-quantitative or semi-empirical approaches including molecular orbital theory and ligand field theory , In parallel with these theoretical descriptions, approximate methodologies are employed, including density functional theory. Exceptions to theories, qualitative and quantitative, are extremely important in the development of the field. The disagreement between qualitative theory paramagnetic and observation diamagnetic led to the development of models for "magnetic coupling.
Inorganic chemistry has greatly benefited from qualitative theories. Such theories are easier to learn as they require little background in quantum theory. Within main group compounds, VSEPR theory powerfully predicts, or at least rationalizes, the structures of main group compounds, such as an explanation for why NH 3 is pyramidal whereas ClF 3 is T-shaped. A particularly powerful qualitative approach to assessing the structure and reactivity begins with classifying molecules according to electron counting , focusing on the numbers of valence electrons , usually at the central atom in a molecule.
A central construct in inorganic chemistry is the theory of molecular symmetry. Group theory also enables factoring and simplification of theoretical calculations. Spectroscopic features are analyzed and described with respect to the symmetry properties of the, inter alia , vibrational or electronic states. Knowledge of the symmetry properties of the ground and excited states allows one to predict the numbers and intensities of absorptions in vibrational and electronic spectra. A classic application of group theory is the prediction of the number of C-O vibrations in substituted metal carbonyl complexes.
The most common applications of symmetry to spectroscopy involve vibrational and electronic spectra. As an instructional tool, group theory highlights commonalities and differences in the bonding of otherwise disparate species, such as WF 6 and Mo CO 6 or CO 2 and NO 2. An alternative quantitative approach to inorganic chemistry focuses on energies of reactions.
This approach is highly traditional and empirical , but it is also useful. Broad concepts that are couched in thermodynamic terms include redox potential , acidity , phase changes. A classic concept in inorganic thermodynamics is the Born-Haber cycle , which is used for assessing the energies of elementary processes such as electron affinity , some of which cannot be observed directly.
An important and increasingly popular aspect of inorganic chemistry focuses on reaction pathways. The mechanisms of reactions are discussed differently for different classes of compounds. The mechanisms of main group compounds of groups are usually discussed in the context of organic chemistry organic compounds are main group compounds, after all. Elements heavier than C, N, O, and F often form compounds with more electrons than predicted by the octet rule , as explained in the article on hypervalent molecules.
Description - summary of the module content
The mechanisms of their reactions differ from organic compounds for this reason. Elements lighter than carbon B , Be , Li as well as Al and Mg often form electron-deficient structures that are electronically akin to carbocations. Such electron-deficient species tend to react via associative pathways. The chemistry of the lanthanides mirrors many aspects of chemistry seen for aluminium. Mechanisms for the reactions of transition metals are discussed differently from main group compounds. These themes are covered in articles on coordination chemistry and ligand.
Both associative and dissociative pathways are observed. The rates of water exchange varies by 20 orders of magnitude across the periodic table, with lanthanide complexes at one extreme and Ir III species being the slowest. Redox reactions are prevalent for the transition elements. Two classes of redox reaction are considered: A fundamental redox reaction is "self-exchange", which involves the degenerate reaction between an oxidant and a reductant. For example, permanganate and its one-electron reduced relative manganate exchange one electron:.
Coordinated ligands display reactivity distinct from the free ligands.
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Alkenes bound to metal cations are reactive toward nucleophiles whereas alkenes normally are not. The large and industrially important area of catalysis hinges on the ability of metals to modify the reactivity of organic ligands.