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Although program director Paul Engle awarded him a fellowship for a second year of study after Maryann Carver personally interceded and compared her husband's plight to Tennessee Williams ' deleterious experience in the program three decades earlier, Carver decided to leave the University of Iowa at the end of the semester. According to biographer Carol Sklenicka , Carver falsely claimed to have received an M. After completing graduate work at Stanford, she briefly enrolled in the University of California, Santa Barbara 's English doctoral program when Carver taught at the institution as a visiting lecturer in In the mids, Carver and his family resided in Sacramento, California , where he briefly worked at a bookstore before taking a position as a night custodian at Mercy Hospital.
He audited classes at what was then Sacramento State College , including workshops with poet Dennis Schmitz. Carver and Schmitz soon became friends, and Carver wrote and published his first book of poems, Near Klamath , under Schmitz's guidance.
He briefly enrolled in the library science graduate program at the University of Iowa that summer but returned to California following the death of his father. Shortly thereafter, the Carvers relocated to Palo Alto, California , so he could take his first white-collar job at Science Research Associates a subsidiary of IBM in nearby Menlo Park, California , where he worked intermittently as a textbook editor and public relations director through Following a sojourn to Israel , the Carvers relocated to San Jose, California ; as Maryann finished her undergraduate degree, he continued his graduate studies in library science at San Jose State through the end of before failing once again to take a degree.
After the publication of "Neighbors" in the June issue of Esquire at the instigation of Lish by now ensconced as the magazine's fiction editor, Carver began to teach at the University of California, Santa Cruz at the behest of provost James B. Hall, an Iowa alumnus and early mentor to Ken Kesey at the University of Oregon , commuting from his new home in Sunnyvale, California.
Annotation of metagenome short reads using proxygenes.
The fellowship enabled the Carvers to buy a house in Cupertino, California. During his years of working at miscellaneous jobs, rearing children, and trying to write, Carver started abusing alcohol. In the fall semester of , Carver was a visiting lecturer in the Iowa Writers' Workshop with John Cheever , but Carver stated that they did less teaching than drinking and almost no writing. With the assistance of Kinder and Kittredge, he attempted to simultaneously commute to Berkeley and maintain his lectureship at Santa Cruz; after missing all but a handful of classes due to the inherent logistical hurdles of this arrangement and various alcohol-related illnesses, Hall gently enjoined Carver to resign his position.
The next year, after leaving Iowa City, Carver went to a treatment center to attempt to overcome his alcoholism , but continued drinking for another three years. The collection itself was shortlisted for the National Book Award , though it sold fewer than 5, copies that year. The following excerpt from Scott Driscoll's review  of Maryann Burk Carver's memoir  describes the decline of Maryann's and Raymond's marriage. The fall began with Ray's trip to Missoula, Mont. That summer Ray fell in love with Diane Cecily, an editor at the University of Montana, whom he met at Kittredge's birthday party.
It broke my heart and hurt the children. I had to drop out of the Ph. Over the next several years, Maryann's husband physically abused her. Friends urged her to leave Raymond. I really wanted to hang in there for the long haul. I thought I could outlast the drinking.
I'd do anything it took. I loved Ray, first, last and always. Carver describes, without a trace of rancor, what finally put her over the edge. In the fall of '78, with a new teaching position at the University of Texas at El Paso , Ray started seeing Tess Gallagher, a writer from Port Angeles , who would become his muse and wife near the end of his life.
He tried to call me to talk about where we were.
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I missed the calls. He knew he was about to invite Tess to Thanksgiving. Here it was, coming at me again, the same thing. I had to get on with my own life. But I never fell out of love with him. After being hospitalized three times between June and February or March , Carver began his "second life" and stopped drinking on June 2, , with the help of Alcoholics Anonymous.
Raymond Carver - Wikipedia
In , the two moved to Syracuse, New York , where Gallagher had been appointed the coordinator of the creative writing program at Syracuse University ; Carver taught as a professor in the English department. He and Gallagher jointly purchased a house in Syracuse, at Maryland Avenue. In ensuing years, the house became so popular that the couple had to hang a sign outside that read "Writers At Work" in order to be left alone. In , he and his first wife, Maryann, were divorced.
It was only in , six weeks prior to his death that Carver and Gallagher married in Reno, Nevada. In the same year, he was inducted into the American Academy of Arts and Letters. The inscription on his tombstone reads:.
And what did you want? To call myself beloved, to feel myself beloved on the earth. As Carver's will directed, Tess Gallagher assumed the management of his literary estate. Carver was nominated for the National Book Award and the Pulitzer Prize for Fiction for his third major-press collection, Cathedral , the volume generally perceived as his best. For his part, Carver perceived Cathedral as a watershed in his career for its shift toward a more optimistic and confidently poetic style amid the diminution of Lish's literary influence.
In Carver's birth town of Clatskanie, Oregon, a memorial park and statue are at the corner of Lillich and Nehalem Streets, across from the library. A block away is the building where Carver was born. In December , Gallagher published an essay in The Sun magazine , titled "Instead of Dying", about alcoholism and Carver's having maintained his sobriety. The first lines read: I would meet him five months after this choice, so I never knew the Ray who drank, except by report and through the characters and actions of his stories and poems. A typical metagenome dataset generated using a pyrosequencing platform consists of short reads sampled from the collective genome of a microbial community.
The amount of sequence in such datasets is usually insufficient for assembly, and traditional gene prediction cannot be applied to unassembled short reads. As a result, analysis of such datasets usually involves comparisons in terms of relative abundances of various protein families. The latter requires assignment of individual reads to protein families, which is hindered by the fact that short reads contain only a fragment, usually small, of a protein. Using simulated metagenome datasets as benchmarks, we show that the proxygene method is more accurate than the direct assignment.
We introduce a clustering method which significantly reduces the size of a metagenome dataset while maintaining a faithful representation of its functional and taxonomic content.